Design and Analysis of Cross-Over Trials

Discover the essential insights of clinical trial design with the third edition of Design and Analysis of Cross-Over Trials by Byron Jones, published by Taylor & Francis Ltd in 2024. This comprehensive guide spans 438 pages and is a must-read for professionals in medical statistics and pharmacology.

This updated edition introduces new chapters that delve into critical topics such as re-estimating sample size for average bioequivalence testing, fitting nonlinear dose-response functions, and effectively estimating doses to transition from phase two to phase three trials. Additionally, it explores the establishment of proof of concept and the recalculation of sample size using conditional power.

Whether you are a seasoned researcher or a student in the field, this book is an invaluable resource that combines theoretical knowledge with practical applications, ensuring you are well-equipped to navigate the complexities of cross-over trials.